Widefield, laser widefield, TIRF, spectral confocal imaging, and super-resolution? The ELYRA can do it all! Using structured illumination, this system can improve resolution in X, Y, and Z two-fold – with no special sample prep needed. If that isn’t sufficient for your experiment, photomanipulation super-resolution techniques like PALM or dSTORM can improve your resolution by as much as an order of magnitude! Clicking a button in the ZEISS software easily switches between imaging modes, allowing you to image the same sample by a variety of techniques.
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Two-photon illumination has always appealed to biologists for imaging deep into living tissue. But did you ever imagine probing more than 5mm into your sample? Using the 780 NLO with our specialized SCAlE objective, you can visualize deep into clarified tissue with incredible resolution. Even without clarifying your samples, this microscope excels at penetrating deep into live or fixed specimens, and creating beautiful 3D datasets.
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Combining a 16x zoom with high numerical aperture objectives, the AxioZoom.V16 offers superior brightness in large object fields. This highly versatile microscope can image samples illuminated by transmitted, reflected, polarized, and fluorescent light sources, and is equipped with high resolution color and monochrome cameras. The AxioZoom.V16 also boasts an Apotome, an optical sectioning device, capable of creating large field 3D images.
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So you have a four-color sample that requires 3D imaging over large tiled areas? Then the LSM 700 is the microscope for you. This incredibly user-friendly point scanner can image four channels simultaneously, due to its unique Variable Secondary Dichroic, all the while acquiring 3D images over multiple fields of view.
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Even the world’s greatest surgeon might struggle with dissecting single cells out of a slice of tissue. With the PALM system, laser microdissection, catapult and capture is as easy as drawing a region to dissect on the screen, and pressing start. Remove individual cells from your samples slices, or excise entire subregions for RT-PCR, DNA, or even mass spec analysis.
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Have you ever looked at a giant pile of slides, and wondered how you'll find the time to image them all? The Axio Scan.Z1 is your answer! This high speed slide scanner has an astonishing 100-slide capacity, and can image samples stained with both colormetric and fluorescent dyes. Load your slides, let the software automatically locate your tissue sections, and off you go!
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Trains on all microscopes.
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Trains on all microscopes.
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Have you ever looked at a giant pile of slides, and wondered how you'll find the time to image them all? The Axio Scan.Z1 is your answer! This high speed slide scanner has an astonishing 100-slide capacity, and can image samples stained with both colormetric and fluorescent dyes. Load your slides, let the software automatically locate your tissue sections, and off you go!
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Trains on all microscopes.
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Long-term, high-speed 3D imaging with virtually no phototoxicity or bleaching may sound too good to be true, but the Lightsheet.Z1 delivers. This brand new microscope from ZEISS is the first of its kind to be installed in North America! Samples are immobilized in agarose or tubing, immersed in a buffer of your choosing, and can be freely rotated during imaging. 3D imaging that previously took hours on a point scanner can now be accomplished in mere minutes!
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The LSM 880 confocal microscope offers 34-channels of supreme sensitivity, owing to its GaAsP detectors with the added bonus of a super-resolution Airyscanner. This extraordinary point scanner can simultaneously image and spectrally separate up to 10 different dyes, create high resolution 3D images over large tiled areas, or image single molecules through fluorescence correlation techniques. The unparalleled sensitivity of this system also makes it the ideal live-cell imaging point scanner, allowing for high-speed confocal acquisition with brilliant signal to noise ratios. The Airy Scan array detector removes the requirement for a pinhole allowing ALL of the light collected from your sample to reach the detector. And additional deconvolution provides a 1.7x improvement over the theoretical diffraction limit.
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The MERSCOPE uses MERFISH technology to directly map and quantify the spatial distribution of hundreds to tens of thousands of RNA species in individual cells, without the need for downstream sequencing.
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The LSM 900 is optimal for confocal imaging with the four commonly used dyes. The entire system is fully motorized for autofocusing over large fields of view. It comes with an artificial intelligent (AI) Sample finder that enables the user to map their sample with flexibility to zone in on regions of interest. In addition to the confocal GaAsP detectors, the system has an Axiocam camera and an ESID for widefield fluorescence or transmitted light imaging.
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High-end PC for graphics work running Volocity software from Improvision for 3D rendering and analysis of data including confocal data sets. In addition, this computer runs the free image-processing packages ImageJ and Fiji.
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High-end PC for graphics work running ZEN Black Lightsheet addition. The computer features 15TB of data storage and is EXCLUSIVELY used for processing data sets acquired on the Lightsheet microscope.
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High-end PC for graphics work running ZEN Black Lightsheet addition. The computer features 15TB of data storage and is EXCLUSIVELY used for processing data sets acquired on the Lightsheet microscope.
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High-end PC for graphics work running ZEN Black Lightsheet addition. The computer features 15TB of data storage and is EXCLUSIVELY used for processing data sets acquired on the Lightsheet microscope.
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High-end PC for graphics work which includes a number of ZEN Black and ZEN Blue releases. The station is primarily used for processing 3DSIM and PALM/STORM data.
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High-end PC for graphics work which includes a number of ZEN Black and ZEN Blue releases. The station is primarily used for processing 3DSIM and PALM/STORM data.
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High-end PC for graphics work which includes a number of ZEN Black and ZEN Blue releases. The station is primarily used for processing 3DSIM and PALM/STORM data.
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High-end PC for graphics work which includes a number of ZEN Black and ZEN Blue releases. The station is primarily used for processing 3DSIM and PALM/STORM data.
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High-end PC for graphics work which includes a number of ZEN Black and ZEN Blue releases. The station is primarily used for processing 3DSIM and PALM/STORM data.
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High-end PC for graphics work which includes a number of ZEN Black and ZEN Blue releases. The station is primarily used for processing 3DSIM and PALM/STORM data.
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The LSM 900 is optimal for confocal imaging with the four commonly used dyes. The entire system is fully motorized for autofocusing over large fields of view. It comes with an artificial intelligent (AI) Sample finder that enables the user to map their sample with flexibility to zone in on regions of interest. In addition to the confocal GaAsP detectors, the system has an Axiocam camera and an ESID for widefield fluorescence or transmitted light imaging.
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Please include the following acknowledgement in any publications utilizing HCBI resources: We thank the Harvard Center for Biological Imaging (RRID:SCR_018673) for infrastructure and support.
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